Nutritional Supplements’ Influence on Epigenetic Aging and Inflammation in Older Adults

In a 12-week research study published in “GeroScience”, scientists from the University of Birmingham and Hurdle evaluated the effects of a nutritional supplement on aging indicators and inflammation in older adults. This open-label trial included 80 healthy older participants who were administered daily doses during 12-weeks of Omega-3 fatty acids, vitamins B3, C, D, resveratrol, olive fruit phenols and astaxanthin. While the group as a whole did not show significant changes, notable improvements were observed in participants with high baseline levels of C-reactive protein (CRP) and those with accelerated epigenetic age.

Importantly, the only epigenetic clock that detected a significant effect was the new saliva-based InflammAge clock developed by Hurdle, which shows that this biomarker is actionable and captures the effects of anti-inflammatory interventions. 

Professor Janet Lord from the University of Birmingham remarked, “Working with Hurdle to test their new aging clock was a great experience and revealed a biomarker that is sensitive to intervention in older adults.” 

Dr. Daniel E. Martin-Herranz, CSO at, commented on the importance of biomarkers in clinical research: “This is a clear use case for the importance of developing accurate and robust biomarkers of human ageing to advance cutting-edge longevity therapies. By leveraging our novel epigenetic biomarker for chronic inflammation, we were able to both stratify responders and detect a potential effect of the intervention.”

Dr. Tom Stubbs, CEO of, emphasized the importance of tailored health interventions, stating, “This study highlights the importance of precision approaches to health and longevity. One size does not fit all when it comes to health.” These results underline the potential of personalized nutritional strategies in managing ageing, particularly in individuals with specific health profiles, and encourage further research to explore these effects more broadly.

The original scientific article, titled: “A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age”. Can be found here.